Scientists at the University of Melbourne have discovered the local action of immune cells in the skin, which could improve treatment of viral skin infections.
This work identifies previously unrecognised first-line defence mechanisms that are particularly important in barrier locations such as the skin and the gut, often used as portals of entry by viruses and bacteria.
Researchers examined two aspects of anti-viral immune responses by studying the cells involved in the initial stimulation of the immune response, and the cells that remember past infections to boost the response after reinfection. They did this by using a model infection with herpes simplex virus - a virus best known for causing cold sores but also associated with life threatening diseases in certain individuals and newborns.
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